MRC Epidemiology Unit

 

Long-term effects of intensive multifactorial therapy in individuals with screen-detected type 2 diabetes in primary care: 10-year follow-up of the ADDITION-Europe cluster-randomised trial.

Griffin SJ, Rutten GEHM, Khunti K, Witte DR, Lauritzen T, Sharp SJ, Dalsgaard EM, Davies MJ, Irving GJ, Vos RC, Webb DR, Wareham NJ, and Sandbæk A

The lancet. Diabetes & endocrinology. Nov 2018

(DOI : 10.1016/S2213-8587(19)30349-3)

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The role of physical activity in the development of first cardiovascular disease event: a tree-structured survival analysis of the Danish ADDITION-PRO cohort.

Amadid H, Johansen NB, Bjerregaard AL, Brage S, Færch K, Lauritzen T, Witte DR, Sandbæk A, Jørgensen ME, and Vistisen D

Cardiovascular diabetology. Apr 2018

(DOI : 10.1186/s12933-018-0769-x)

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Effect of screening for type 2 diabetes on healthcare costs: a register-based study among 139,075 individuals diagnosed with diabetes in Denmark between 2001 and 2009.

Sortsø C, Komkova A, Sandbæk A, Griffin SJ, Emneus M, Lauritzen T, and Simmons RK

Diabetologia. Sep 2017

(DOI : 10.1007/s00125-018-4594-2)

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Physical Activity Dimensions Associated with Impaired Glucose Metabolism.

Amadid H, Johansen NB, Bjerregaard AL, Vistisen D, Færch K, Brage S, Lauritzen T, Witte DR, Sandbæk A, and Jørgensen ME

Medicine and Science in Sports and Exercise. Jul 2017

(DOI : 10.1249/MSS.0000000000001362)

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Effect of population screening for type 2 diabetes and cardiovascular risk factors on mortality rate and cardiovascular events: a controlled trial among 1,912,392 Danish adults.

Simmons RK, Griffin SJ, Witte DR, Borch-Johnsen K, Lauritzen T, and Sandbæk A

Diabetologia. Mar 2017

(DOI : 10.1007/s00125-017-4323-2)

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Effect of screening for type 2 diabetes on risk of cardiovascular disease and mortality: a controlled trial among 139,075 individuals diagnosed with diabetes in Denmark between 2001 and 2009.

Simmons RK, Griffin SJ, Lauritzen T, and Sandbæk A

Diabetologia. Jan 2017

(DOI : 10.1007/s00125-017-4299-y)

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A randomised trial of the effect and cost-effectiveness of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with screen-detected type 2 diabetes: the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe) study.

Simmons RK, Borch-Johnsen K, Lauritzen T, Rutten GE, Sandbæk A, van den Donk M, Black JA, Tao L, Wilson EC, Davies MJ, Khunti K, Sharp SJ, Wareham NJ, and Griffin SJ

Health technology assessment (Winchester, England). Sep 2016

(DOI : 10.3310/hta20640)

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Does Training and Support of General Practitioners in Intensive Treatment of People with Screen-Detected Diabetes Improve Medication, Morbidity and Mortality in People with Clinically-Diagnosed Diabetes? Investigation of a Spill-Over Effect in a Cluster RCT.

Charles M, Skriver MV, Griffin SJ, Simmons RK, Witte DR, Dalsgaard EM, Lauritzen T, and Sandbæk A

PLoS ONE. Jul 2016

(DOI : 10.1371/journal.pone.0170697)

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Higher physical activity is associated with lower aortic stiffness but not with central blood pressure: the ADDITION-Pro Study.

Laursen AS, Hansen AL, Wiinberg N, Brage S, Sandbæk A, Lauritzen T, Witte DR, Jørgensen ME, and Johansen NB

Medicine. Feb 2015

(DOI : 10.1097/MD.0000000000000485)

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Effect of early multifactorial therapy compared with routine care on microvascular outcomes at 5 years in people with screen-detected diabetes: a randomized controlled trial: the ADDITION-Europe Study.

Sandbæk A, Griffin SJ, Sharp SJ, Simmons RK, Borch-Johnsen K, Rutten GE, van den Donk M, Wareham NJ, Lauritzen T, Davies MJ, and Khunti K

Diabetes care. May 2014

(DOI : 10.2337/dc13-1544)

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Change in cardiovascular risk factors following early diagnosis of type 2 diabetes: a cohort analysis of a cluster-randomised trial.

Black JA, Sharp SJ, Wareham NJ, Sandbæk A, Rutten GE, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Griffin SJ, and Simmons RK

The British journal of general practice : the journal of the Royal College of General Practitioners. Apr 2014

(DOI : 10.3399/bjgp14X677833)

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Effect of early intensive multifactorial therapy compared with routine care on self-reported health status, general well-being, diabetes-specific quality of life and treatment satisfaction in screen-detected type 2 diabetes mellitus patients (ADDITION-Europe): a cluster-randomised trial.

van den Donk M, Griffin SJ, Stellato RK, Simmons RK, Sandbæk A, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Wareham NJ, and Rutten GE

Diabetologia. Apr 2013

(DOI : 10.1007/s00125-013-3011-0)

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Protocol for ADDITION-PRO: a longitudinal cohort study of the cardiovascular experience of individuals at high risk for diabetes recruited from Danish primary care.

Johansen NB, Hansen AL, Jensen TM, Philipsen A, Rasmussen SS, Jørgensen ME, Simmons RK, Lauritzen T, Sandbæk A, and Witte DR

BMC Public Health. Nov 2012

(DOI : 10.1186/1471-2458-12-1078)

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Does early intensive multifactorial treatment reduce total cardiovascular burden in individuals with screen-detected diabetes? Findings from the ADDITION-Europe cluster-randomized trial.

Simmons RK, Sharp SJ, Sandbæk A, Borch-Johnsen K, Davies MJ, Khunti K, Lauritzen T, Rutten GE, van den Donk M, Wareham NJ, and Griffin SJ

Diabetic medicine : a journal of the British Diabetic Association. Jul 2012

(DOI : 10.1111/j.1464-5491.2012.03759.x)

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Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial.

Griffin SJ, Borch-Johnsen K, Davies MJ, Khunti K, Rutten GE, Sandbæk A, Sharp SJ, Simmons RK, van den Donk M, Wareham NJ, and Lauritzen T

Lancet (London, England). Jun 2011

(DOI : 10.1016/S0140-6736(11)60698-3)

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