Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
Human Molecular Genetics 2009 ; 18: 3508-15.
Qi Q, Li H, Loos RJ, Liu C, Wu Y, Hu FB, Wu H, Lu L, Yu Z, and Lin X
DOI : 10.1093/hmg/ddp294
PubMed ID : 19556355
PMCID : 0
Common variants in KCNQ1 have recently been reported to be associated with type 2 diabetes in East Asians. We aimed to examine whether these common variants (rs2074196, rs2237892, rs2237895 and rs2237897) were also associated with type 2 diabetes in a population-based cohort of 3210 Chinese Hans and to explore the underlying mechanisms. The SNPs rs2237892, rs2237895 and rs2237897 were significantly associated with type 2 diabetes (OR: 1.33-1.36, P