No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults.
Journal of psychiatric research 2005 ; 41: 404-9.
Surtees PG, Wainwright NW, Willis-Owen SA, Sandhu MS, Luben R, Day NE, and Flint J
DOI : 10.1016/j.jpsychires.2006.01.004
PubMed ID : 16497333
URL : https://linkinghub.elsevier.com/retrieve/pii/S0022395606000185
Recent research has suggested that brain-derived neurotrophic factor (BDNF) may be implicated in the aetiology of mood-related phenotypes. Here we report an investigation of the association between a BDNF coding variant (Val66Met, rs6265) and mood status in a large non-clinical sample of men and women. We genotyped 7389 adult men and women, aged 41-80 years, selected from participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk, United Kingdom). Evidence of past year prevalent, lifetime and recurrent episodic major depressive disorder (MDD) and of past year prevalent and lifetime generalised anxiety disorder (GAD), defined by DSM-IV diagnostic criteria, was assessed through questionnaire together with a five-item version of the Mental Health Inventory (MHI-5). A total of 1214 (16.4%) participants reported lifetime MDD and 355 (4.8%) reported lifetime GAD. In this population based study we found no evidence to support an association between the BDNF gene Val66Met polymorphism and mood status.